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What is PDRN?

Polydeoxyribonucleotide

An ingredient made from salmon DNA that moved from wound-healing research into skincare.

✓ Mature skin✓ Fine lines✓ Tired-looking skin✓ Post-acne care

What is PDRN?

PDRN is made by purifying DNA from salmon or trout sperm and breaking it into small fragments. In Italy it has been injected for wound and burn treatment for many years. In Korea it first became known through "salmon DNA" injections at dermatology clinics, and over the last few years it has made its way into serums and ampoules. In a cosmetic, the aim is to help skin look fresher and plumper. Do not expect a serum you apply at home to work like PDRN injected at a clinic; studies on topical products are still few.

How it works

PDRN binds to adenosine A2A receptors on cells. In lab and animal studies this stimulated collagen-producing fibroblasts, reduced inflammation and sped up tissue repair. The DNA fragments can also be reused by cells to build new DNA. Most of this evidence comes from injection and wound-healing studies.

📋 How to use

A few drops at the serum step, after cleansing and toner. Evening use is common, but it can go on in the morning too. If the product also contains retinol (for example the PDRN Retinol Ampoule), start with 2 to 3 evenings a week, increase as your skin adjusts and always wear sunscreen during the day.

⚠️ Side effects and warnings

Topical PDRN is generally well tolerated. If you are allergic to fish products, ask your doctor first. With PDRN products that contain retinol, dryness, flaking and stinging usually come from the retinol. Avoid retinol products during pregnancy and breastfeeding, and ask your doctor about pure PDRN products too.

Related K-LAB products

Rivecowe PDRN Retinol Ampoule 30 ml - Revitalising Serum for Oily Skin

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Frequently asked questions

Is PDRN made from salmon?

Yes. Cosmetic PDRN is usually made of DNA fragments purified from salmon or trout sperm, so it is not vegan.

Can I use PDRN and retinol together?

Yes; some products contain both. If you are new to retinol, start slowly to lower the risk of irritation and build up as your skin adjusts.

When will I see results?

Changes in skin usually take at least 4 to 8 weeks of regular use. Results vary from person to person, so we would rather not promise a fixed timeline.

Is it the same as clinic "salmon DNA" treatments?

Same ingredient, different method. At a clinic PDRN is injected into the skin; a serum sits on the surface and far less reaches deeper layers. Do not expect the same effect.

Can I use it during pregnancy?

There is not enough data on topical PDRN in pregnancy. Retinol products are not recommended during pregnancy or breastfeeding. Ask your doctor before starting any new product in this period.

Medical disclaimer: The information on this page is general and does not replace medical advice. If your skin is sensitive, you have allergies or an ongoing skin condition, ask your dermatologist before trying a new ingredient.